Description

Methyl 3-Hydroxy-4-((Trimethylsilyl)Ethynyl)Benzoate is a high-value, multi-functional synthetic intermediate characterized by its unique combination of a silyl-protected alkyne and a benzoate ester group. This compound is critical for advanced organic synthesis, offering a versatile handle for cross-coupling reactions and further functionalization. It is primarily sought after by research and development teams in the pharmaceutical and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting neurological and oncological pathways.
• Organic Synthesis Reagent: Used in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to introduce acetylene functionalities into complex molecules.
• Ligand and Catalyst Precursor: Serves as a starting material for the development of novel ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic semiconductors, conductive polymers, and advanced organic frameworks (MOFs/COFs).
• Agrochemical Synthesis: Intermediate in the research and development of new generation herbicides and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodological development and exploring new chemical space in university and corporate research laboratories.

Basic Information

Product Name	Methyl 3-Hydroxy-4-((Trimethylsilyl)Ethynyl)Benzoate
CAS No.	478169-68-5
Molecular Formula	C13H16O3Si
Molecular Weight	248.35 g/mol
Synonyms	Benzoic acid, 3-hydroxy-4-[(trimethylsilyl)ethynyl]-, methyl ester; Methyl 3-hydroxy-4-((trimethylsilyl)ethynyl)benzoate; 4-((Trimethylsilyl)ethynyl)-3-hydroxybenzoic acid methyl ester; Methyl 4-((trimethylsilyl)ethynyl)-3-hydroxybenzoate; 3-Hydroxy-4-((trimethylsilyl)ethynyl)benzoic acid methyl ester; CAS 478169-68-5
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Hydroxy-4-((Trimethylsilyl)Ethynyl)Benzoate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.