Description

2-[4-(Benzylsulfonyl)Piperazino]-4,6-Dimethylnicotinonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique piperazine-linked nicotinonitrile core. This compound is valued for its role as a critical building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is essential for pharmaceutical companies and research institutions focused on developing new therapeutic agents, especially within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Kinase Inhibitor Development: Serves as a core structure in the research of novel kinase inhibitors for oncology applications.
• CNS Drug Discovery: Employed in the design and synthesis of compounds intended to cross the blood-brain barrier.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for exploratory chemical biology and pharmacology projects.

Basic Information

Product Name	2-[4-(Benzylsulfonyl)Piperazino]-4,6-Dimethylnicotinonitrile
CAS No.	478081-75-3
Molecular Formula	C20H22N4O2S
Molecular Weight	382.48 g/mol
Synonyms	4,6-Dimethyl-2-[4-(phenylmethylsulfonyl)-1-piperazinyl]-3-pyridinecarbonitrile; 2-(4-Benzylsulfonylpiperazin-1-yl)-4,6-dimethylnicotinonitrile; 4,6-Dimethyl-2-(4-(phenylmethylsulfonyl)piperazin-1-yl)nicotinonitrile; BZSP-DMN; CAS 478081-75-3
EINECS	Contact for details

Quality Control

Our 2-[4-(Benzylsulfonyl)Piperazino]-4,6-Dimethylnicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.