Description

4-(4-Chlorophenyl)-2-Oxo-1-[3-(Trifluoromethyl)Benzyl]-1,2-Dihydro-3-Pyridinecarbonitrile is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its precise molecular architecture, which serves as a critical building block in modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs), especially those targeting specific protein receptors.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in academic and industrial R&D labs.
• Oncology Drug Development: Employed in the synthesis of potential kinase inhibitors and other targeted cancer therapies.
• CNS Drug Discovery: Utilized as a building block for compounds intended to cross the blood-brain barrier.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	4-(4-Chlorophenyl)-2-Oxo-1-[3-(Trifluoromethyl)Benzyl]-1,2-Dihydro-3-Pyridinecarbonitrile
CAS No.	478080-36-3
Molecular Formula	C20H12ClF3N2O
Molecular Weight	388.77 g/mol
Synonyms	1-(3-(Trifluoromethyl)benzyl)-4-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile; 4-(4-Chlorophenyl)-1-((3-(trifluoromethyl)phenyl)methyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile; 3-Cyano-4-(4-chlorophenyl)-1-[(3-trifluoromethyl)benzyl]-2(1H)-pyridinone; 478080-36-3; 1-(3-(Trifluoromethyl)benzyl)-4-(4-chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 4-(4-Chlorophenyl)-2-Oxo-1-[3-(Trifluoromethyl)Benzyl]-1,2-Dihydro-3-Pyridinecarbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from incompatible materials such as strong acids, strong bases, and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.