Description

8-Chloro-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine is a high-value, heterocyclic organic compound featuring a fused triazolopyridine core substituted with chloro and trifluoromethyl groups. This unique structure makes it a critical advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. The compound's properties are leveraged to modulate the bioavailability, metabolic stability, and binding affinity of target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly in oncology, CNS disorders, and anti-infective therapeutic areas.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and insecticides, leveraging the biological activity of the triazolopyridine scaffold.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to explore new chemical space and optimize lead compounds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Material Science Research: Investigated as a component for advanced organic electronic materials due to its electron-deficient aromatic system.

Basic Information

Product Name	8-Chloro-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine
CAS No.	478066-06-7
Molecular Formula	C7H3ClF3N3
Molecular Weight	221.57 g/mol
Synonyms	8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine; 6-(Trifluoromethyl)-8-chloro-[1,2,4]triazolo[4,3-a]pyridine; [1,2,4]Triazolo[4,3-a]pyridine, 8-chloro-6-(trifluoromethyl)-; 8-Chloro-6-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine
EINECS	Contact for details

Quality Control

Our 8-Chloro-6-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.