Description

6-Cyclopropyl-2-(Diethylamino)-4-(Trifluoromethyl)Nicotinonitrile is a specialized, high-value pyridine derivative building block designed for advanced chemical synthesis. This compound is critical for research and development in the pharmaceutical and agrochemical sectors, where its unique trifluoromethyl and diethylamino substituents enable the creation of novel bioactive molecules. It is primarily sought after by medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used to construct advanced pyridine-based scaffolds for next-generation herbicides and fungicides.
• Material Science Research: Serves as a building block for developing specialty chemicals and functional materials with tailored properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of complex molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery and development pipelines.

Basic Information

Product Name	6-Cyclopropyl-2-(Diethylamino)-4-(Trifluoromethyl)Nicotinonitrile
CAS No.	478049-67-1
Molecular Formula	C14H16F3N3
Molecular Weight	283.30 g/mol
Synonyms	2-(Diethylamino)-6-cyclopropyl-4-(trifluoromethyl)nicotinonitrile; 6-Cyclopropyl-2-(diethylamino)-4-(trifluoromethyl)pyridine-3-carbonitrile; 4-(Trifluoromethyl)-6-cyclopropyl-2-(diethylamino)-3-cyanopyridine; 2-Diethylamino-6-cyclopropyl-4-trifluoromethylnicotinonitrile; Nicotinonitrile, 6-cyclopropyl-2-(diethylamino)-4-(trifluoromethyl)-; 478049-67-1
EINECS	Contact for details

Quality Control

Our 6-Cyclopropyl-2-(Diethylamino)-4-(Trifluoromethyl)Nicotinonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.