Description

1,8-Naphthyridine-2-Acetonitrile,5,7-Bis(Trifluoromethyl)-α-[4-(Trifluoromethyl)Phenyl]-(9Ci) is a high-value, multi-fluorinated heterocyclic building block designed for advanced chemical synthesis. This compound matters for its unique structural framework, which combines a naphthyridine core with multiple trifluoromethyl groups, offering significant potential for modulating the electronic and steric properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors, antiviral agents, and anti-cancer compounds.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, where the trifluoromethyl groups contribute to improved lipophilicity and biological activity.
• Material Science: Acts as a specialized monomer or ligand for constructing advanced organic electronic materials, such as OLEDs or conductive polymers.
• Chemical Biology: Employed as a molecular probe or tag due to its distinct fluorinated signature, useful in bioimaging and assay development.
• Catalyst & Ligand Design: The nitrogen-rich naphthyridine structure makes it a candidate for designing novel metal-organic frameworks (MOFs) or asymmetric catalysts.
• Custom Synthesis & Contract Manufacturing: A key building block for custom synthesis houses serving clients in life sciences and specialty chemicals.

Basic Information

Item	Details
Product Name	1,8-Naphthyridine-2-Acetonitrile,5,7-Bis(Trifluoromethyl)-α-[4-(Trifluoromethyl)Phenyl]-(9Ci)
CAS No.	478049-39-7
Molecular Formula	C₂₀H₉F₉N₂
Molecular Weight	472.29 g/mol
Synonyms	5,7-Bis(trifluoromethyl)-α-[4-(trifluoromethyl)phenyl]-1,8-naphthyridine-2-acetonitrile; 2-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-3-[4-(trifluoromethyl)phenyl]propanenitrile; α-(4-Trifluoromethylphenyl)-5,7-bis(trifluoromethyl)-1,8-naphthyridine-2-acetonitrile; 478049-39-7; 1,8-Naphthyridine-2-acetonitrile, 5,7-bis(trifluoromethyl)-α-[4-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 1,8-Naphthyridine-2-Acetonitrile,5,7-Bis(Trifluoromethyl)-α-[4-(Trifluoromethyl)Phenyl]-(9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) and spectroscopic confirmation (NMR, MS) are provided to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.