Description

2-Chloro-n-(4-Cyano-3-Methyl-5-Isoxazolyl)Nicotinamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure combining nicotinamide, isoxazole, and cyano functionalities. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), enabling the development of targeted therapies. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, particularly for projects involving enzyme inhibition and the creation of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug candidates, especially in oncology and anti-inflammatory research pipelines.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Development: Functions as a potential intermediate in the research and synthesis of novel herbicides or fungicides with specific modes of action.
• Chemical Biology Probes: Employed in the development of specialized molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects requiring high-fidelity chemical building blocks.

Basic Information

Product Name	2-Chloro-n-(4-Cyano-3-Methyl-5-Isoxazolyl)Nicotinamide
CAS No.	478043-92-4
Molecular Formula	C12H8ClN5O2
Molecular Weight	289.67 g/mol
Synonyms	2-Chloro-N-(4-cyano-3-methyl-1,2-oxazol-5-yl)pyridine-3-carboxamide; 2-Chloronicotinoyl-4-cyano-3-methyl-5-amino-isoxazole; Nicotinamide, 2-chloro-N-(4-cyano-3-methyl-5-isoxazolyl)-; 3-Pyridinecarboxamide, 2-chloro-N-(4-cyano-3-methyl-5-isoxazolyl)-; 478043-92-4; 2-Chloro-N-(4-cyano-3-methylisoxazol-5-yl)nicotinamide
EINECS	Contact for details

Quality Control

Our 2-Chloro-n-(4-Cyano-3-Methyl-5-Isoxazolyl)Nicotinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our commitment to quality supports compliance with cGMP standards where required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.