Description

1,8-Naphthyridine-2-Acetonitrile,α-(4-Fluorophenyl)-5,7-Bis(Trifluoromethyl)-(9Ci) is a high-value, multi-fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its complex molecular architecture, featuring a naphthyridine core and multiple trifluoromethyl groups, makes it a critical intermediate for developing novel compounds with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries, where it is used to create new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly for targets requiring fluorinated heterocycles to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorine atoms and naphthyridine structure can enhance biological activity and environmental persistence.
• Material Science: Acts as a building block for creating specialized fluorinated polymers, liquid crystals, or organic electronic materials that require specific electronic and steric properties.
• Chemical Biology & Probe Development: Employed in the design of molecular probes and tags for studying biological systems, leveraging its unique fluorescence or binding characteristics.
• Catalyst & Ligand Synthesis: Utilized to construct complex, nitrogen-containing ligands for transition metal catalysis, enabling new synthetic transformations.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, particularly in cross-coupling and fluorination chemistry research.

Basic Information

Product Name	1,8-Naphthyridine-2-Acetonitrile,α-(4-Fluorophenyl)-5,7-Bis(Trifluoromethyl)-(9Ci)
CAS No.	478043-28-6
Molecular Formula	C₁₉H₉F₇N₂
Molecular Weight	398.28 g/mol
Synonyms	α-(4-Fluorophenyl)-5,7-bis(trifluoromethyl)-1,8-naphthyridine-2-acetonitrile; 2-[2-(4-Fluorophenyl)-2-oxoethyl]-5,7-bis(trifluoromethyl)-1,8-naphthyridine-3-carbonitrile; 478043-28-6; 5,7-Bis(trifluoromethyl)-α-(4-fluorophenyl)-1,8-naphthyridine-2-acetonitrile; 1,8-Naphthyridine-2-acetonitrile, α-(4-fluorophenyl)-5,7-bis(trifluoromethyl)-; (9CI)
EINECS	Contact for details

Quality Control

Our 1,8-Naphthyridine-2-Acetonitrile,α-(4-Fluorophenyl)-5,7-Bis(Trifluoromethyl)-(9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.