Description

1,8-Naphthyridine-2-Acetonitrile,α-(4-Methylphenyl)-5,7-Bis(Trifluoromethyl)-(9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure and trifluoromethyl substituents. This compound is of significant commercial value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high potency and metabolic stability. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing next-generation small-molecule drugs and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a specialized monomer or ligand in the creation of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probe: Utilized in academic and industrial research to study enzyme inhibition and protein-ligand interactions due to its distinctive molecular scaffold.
• Fluorinated Compound Synthesis: Acts as a critical fluorinated synthon for introducing trifluoromethyl motifs into target molecules, a common strategy in modern medicinal chemistry.

Basic Information

Product Name	1,8-Naphthyridine-2-Acetonitrile,α-(4-Methylphenyl)-5,7-Bis(Trifluoromethyl)-(9Ci)
CAS No.	478043-26-4
Molecular Formula	C₂₀H₁₁F₆N₃
Molecular Weight	407.32 g/mol
Synonyms	α-(4-Methylphenyl)-5,7-bis(trifluoromethyl)-1,8-naphthyridine-2-acetonitrile; 2-[2-(4-Methylphenyl)-2-oxoethyl]-5,7-bis(trifluoromethyl)-1,8-naphthyridine-3-carbonitrile; 478043-26-4; 5,7-Bis(trifluoromethyl)-α-(p-tolyl)-1,8-naphthyridine-2-acetonitrile; (4-Methylphenyl)[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]acetonitrile
EINECS	Contact for details

Quality Control

Every batch of 1,8-Naphthyridine-2-Acetonitrile,α-(4-Methylphenyl)-5,7-Bis(Trifluoromethyl)-(9Ci) is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.