Description

1-(3-Fluorobenzyl)-4-(Methylsulfanyl)-2-Oxo-6-Phenyl-1,2-Dihydro-3-Pyridinecarbonitrile is a high-purity, advanced pharmaceutical intermediate with a distinct pyridinecarbonitrile core structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for complex small molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the research and synthesis of new chemical entities (NCEs) for drug discovery programs.
• API Synthesis: Used in the development and scale-up of Active Pharmaceutical Ingredients, especially those targeting neurological or oncological pathways.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies due to its fluorobenzyl and methylsulfanyl functional groups.
• Process Chemistry: Employed in route scouting and optimization for the commercial manufacturing of complex heterocyclic compounds.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring specialized fluorinated intermediates.
• Reference Standard: Can be utilized as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	1-(3-Fluorobenzyl)-4-(Methylsulfanyl)-2-Oxo-6-Phenyl-1,2-Dihydro-3-Pyridinecarbonitrile
CAS No.	478042-99-8
Molecular Formula	C20H15FN2OS
Molecular Weight	350.41 g/mol
Synonyms	3-Cyano-1-(3-fluorobenzyl)-4-(methylthio)-6-phenyl-2(1H)-pyridinone; 4-(Methylsulfanyl)-1-[(3-fluorophenyl)methyl]-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile; 1-(3-Fluorobenzyl)-4-(methylthio)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile; 1-(3-Fluorobenzyl)-4-methylsulfanyl-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile; 478042-99-8; 1-(3-Fluorobenzyl)-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 1-(3-Fluorobenzyl)-4-(Methylsulfanyl)-2-Oxo-6-Phenyl-1,2-Dihydro-3-Pyridinecarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.