Description

L-Tyrosine, o-(2-Tosyloxyethyl)-n-Trityl, tert-Butyl Ester is a sophisticated, multi-protected derivative of the essential amino acid L-tyrosine, designed for advanced synthetic applications. This compound matters as a critical, high-purity building block in the synthesis of complex peptides and bioactive molecules, where precise stereochemistry and functional group manipulation are paramount. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in developing novel therapeutic agents, peptide-based drugs, and specialized biochemical probes.

Application

• Pharmaceutical Intermediate: A key protected precursor in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics targeting various disease pathways.
• Bioconjugation & Probe Development: Used to introduce a functionalized tyrosine moiety into biomolecules for labeling, imaging, or creating antibody-drug conjugates (ADCs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of tyrosine kinase inhibitors or receptor ligands.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of specialized amino acid derivatives, unnatural amino acids, and other high-value chiral compounds.
• Academic & Institutional Research: Utilized in biochemistry and chemical biology laboratories for studying protein function, post-translational modifications, and enzyme mechanisms.

Basic Information

Product Name	L-Tyrosine, o-(2-Tosyloxyethyl)-n-Trityl, tert-Butyl Ester
CAS No.	478037-15-9
Molecular Formula	C41H41NO6S
Molecular Weight	675.84 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-N-trityl-L-tyrosine tert-Butyl Ester; Fmoc-Tyr(2-O-Ts-ethyl)-Trt-OtBu; Fmoc-L-Tyrosine(O-2-tosyloxyethyl)-trityl tert-butyl ester; Protected L-Tyrosine derivative; Nα-Fmoc-Nε-trityl-O-(2-tosyloxyethyl)-L-tyrosine tert-butyl ester; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[4-[2-[(4-methylphenyl)sulfonyloxy]ethoxy]phenyl]-2-(tritylamino)propanoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our L-Tyrosine, o-(2-Tosyloxyethyl)-n-Trityl, tert-Butyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.