Description

4-(3-Chloro-1-Benzothiophen-2-Yl)-2,6-Dimethyl-1,4-Dihydro-3,5-Pyridinedicarbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for process development and scale-up activities.

Application

• Pharmaceutical Intermediate: A key precursor in the research and synthesis of new drug candidates, especially those targeting central nervous system (CNS) disorders or acting as calcium channel modulators.
• Agrochemical Research: Serves as a structural component in the development of new pesticides and herbicides, leveraging its benzothiophene and dihydropyridine motifs.
• Material Science Research: Investigated for potential use in organic electronic materials due to its conjugated π-system and electron-withdrawing nitrile groups.
• Chemical Synthesis: Used in academic and industrial R&D for constructing complex heterocyclic libraries for high-throughput screening.
• Reference Standard: Supplied as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	4-(3-Chloro-1-Benzothiophen-2-Yl)-2,6-Dimethyl-1,4-Dihydro-3,5-Pyridinedicarbonitrile
CAS No.	477886-59-2
Molecular Formula	C₁₈H₁₂ClN₃S
Molecular Weight	337.82 g/mol
Synonyms	4-(3-Chloro-1-benzothiophen-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonitrile; 3,5-Pyridinedicarbonitrile, 4-(3-chloro-1-benzothien-2-yl)-1,4-dihydro-2,6-dimethyl-; 4-(3-Chloro-benzo[b]thiophen-2-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarbonitrile; 1,4-Dihydropyridine-3,5-dicarbonitrile, 4-(3-chloro-1-benzothiophen-2-yl)-2,6-dimethyl-; CAS 477886-59-2
EINECS	Contact for details

Quality Control

Our 4-(3-Chloro-1-Benzothiophen-2-Yl)-2,6-Dimethyl-1,4-Dihydro-3,5-Pyridinedicarbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.