Description

Ethyl 5-Cyano-6-(4-Methylpiperazino)-2-Phenylnicotinate is a high-value, multi-functional heterocyclic building block and pharmaceutical intermediate. Its molecular structure, featuring a cyano group, a substituted piperazine ring, and a phenyl-substituted pyridine core, makes it a versatile synthon for medicinal chemistry research and development. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor research and central nervous system (CNS) active compounds.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and library synthesis due to its reactive cyano and ester functional groups.
• Agrochemical Research: Serves as a core structure for developing new active ingredients in crop protection science.
• Chemical Biology Probe Synthesis: Utilized in the creation of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Academic Research: Used in university and institutional labs for advanced organic synthesis methodologies and novel heterocycle development.

Basic Information

Product Name	Ethyl 5-Cyano-6-(4-Methylpiperazino)-2-Phenylnicotinate
CAS No.	477866-18-5
Molecular Formula	C20H22N4O2
Molecular Weight	350.42 g/mol
Synonyms	Ethyl 5-cyano-6-(4-methyl-1-piperazinyl)-2-phenyl-3-pyridinecarboxylate; 2-Pyridinecarboxylic acid, 5-cyano-6-(4-methyl-1-piperazinyl)-, ethyl ester; 5-Cyano-6-(4-methylpiperazino)-2-phenylnicotinic acid ethyl ester; Ethyl 6-(4-methylpiperazin-1-yl)-5-cyano-2-phenylnicotinate; 477866-18-5; Ethyl 5-cyano-6-(N-methylpiperazino)-2-phenylnicotinate
EINECS	Contact for details

Quality Control

Our Ethyl 5-Cyano-6-(4-Methylpiperazino)-2-Phenylnicotinate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.