Description

Ethyl 6-(4-Benzylpiperazino)-5-Cyano-2-Phenylnicotinate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D laboratories and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the fields of central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the development and scale-up processes for new active pharmaceutical ingredients, especially in neurological and oncological applications.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for exploratory synthetic chemistry and pharmacological studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing outsourced research, development, and manufacturing services to the pharmaceutical industry.

Basic Information

Product Name	Ethyl 6-(4-Benzylpiperazino)-5-Cyano-2-Phenylnicotinate
CAS No.	477866-11-8
Molecular Formula	C26H26N4O2
Molecular Weight	426.52 g/mol
Synonyms	Ethyl 6-(4-benzylpiperazin-1-yl)-5-cyano-2-phenylnicotinate; 2-Pyridinecarboxylic acid, 5-cyano-6-(4-(phenylmethyl)-1-piperazinyl)-, ethyl ester; 6-(4-Benzylpiperazino)-5-cyano-2-phenylnicotinic Acid Ethyl Ester; Ethyl 5-cyano-6-[4-(phenylmethyl)piperazin-1-yl]-2-phenylpyridine-3-carboxylate; 477866-11-8; Nicotinic acid, 5-cyano-6-(4-(phenylmethyl)-1-piperazinyl)-2-phenyl-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 6-(4-Benzylpiperazino)-5-Cyano-2-Phenylnicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliable quality and traceability for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.