Description

Ethyl 5-Cyano-2-Phenyl-6-Piperidinonicotinate is a high-value, multi-functional heterocyclic building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, offering a versatile scaffold for medicinal chemistry research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Development: Serves as a precursor in the research and synthesis of novel crop protection agents and pesticides.
• Chemical Synthesis: Employed in academic and industrial laboratories for the construction of complex piperidine-containing heterocycles and nicotinate derivatives.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and contract research organizations (CROs) specializing in fine chemical production.

Basic Information

Product Name	Ethyl 5-Cyano-2-Phenyl-6-Piperidinonicotinate
CAS No.	477866-04-9
Molecular Formula	C20H21N3O2
Molecular Weight	335.40 g/mol
Synonyms	Ethyl 5-cyano-2-phenyl-6-(piperidin-1-yl)nicotinate; 5-Cyano-2-phenyl-6-(1-piperidinyl)-3-pyridinecarboxylic acid ethyl ester; 3-Pyridinecarboxylic acid, 5-cyano-2-phenyl-6-(1-piperidinyl)-, ethyl ester; Ethyl 5-cyano-2-phenyl-6-(1-piperidyl)nicotinate; 6-Piperidin-1-yl-2-phenyl-nicotinic acid ethyl ester-5-carbonitrile; CAS 477866-04-9
EINECS	Contact for details

Quality Control

Our Ethyl 5-Cyano-2-Phenyl-6-Piperidinonicotinate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) is supplied with every batch, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.