Description

2-(3-Chloro-5-Trifluoromethyl-Pyridinyl)-Malonic Acid Dimethyl Ester is a high-value pyridine-based building block and malonic acid derivative, essential for advanced synthetic chemistry. This compound is critical for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for its role in nucleophilic substitution and condensation reactions.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the biological activity of the trifluoromethylpyridine moiety.
• Material Science Research: Serves as a precursor for functionalized ligands and organic materials in electronic and optoelectronic applications.
• Chemical Biology Probes: Employed in the development of molecular probes and tags for studying biological systems and enzyme activity.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(3-Chloro-5-Trifluoromethyl-Pyridinyl)-Malonic Acid Dimethyl Ester
CAS No.	477859-76-0
Molecular Formula	C12H9ClF3NO4
Molecular Weight	323.65 g/mol
Synonyms	Dimethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)malonate; 2-(3-Chloro-5-(trifluoromethyl)-2-pyridinyl)malonic Acid Dimethyl Ester; 2-(3-Chloro-5-trifluoromethylpyridin-2-yl)malonic Acid Dimethyl Ester; Malonic acid, 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-, dimethyl ester; 477859-76-0; 2-(3-Chloro-5-trifluoromethyl-2-pyridyl)malonic acid dimethyl ester
EINECS	Contact for details

Quality Control

Our 2-(3-Chloro-5-Trifluoromethyl-Pyridinyl)-Malonic Acid Dimethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container must be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.