Description

(1R)-1-(1,4-Dioxa-8-Azaspiro[4.5]Dec-8-Ylmethyl)-2,2,2-Trifluoroethyl 2,6-Difluorobenzenecarboxylate is a high-value, chiral trifluoroethyl ester derivative with a complex spirocyclic structure. This compound matters as a sophisticated chemical intermediate and building block critical for the synthesis of advanced active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to introduce specific stereochemistry and fluorinated motifs into target molecules.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the difluorophenyl and trifluoroethyl groups enhance biological activity and metabolic stability.
• Methodology Development: Serves as a test substrate in organic chemistry research for developing new asymmetric synthesis and fluorination methodologies.
• Ligand and Catalyst Precursor: The spirocyclic amine moiety can be utilized to develop novel chiral ligands or organocatalysts for asymmetric transformations.
• Material Science Research: Potential intermediate for creating specialty fluorinated polymers or advanced materials with unique properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Item	Detail
Product Name	(1R)-1-(1,4-Dioxa-8-Azaspiro[4.5]Dec-8-Ylmethyl)-2,2,2-Trifluoroethyl 2,6-Difluorobenzenecarboxylate
CAS No.	477762-58-6
Molecular Formula	C18H20F5NO4
Molecular Weight	409.35 g/mol
Synonyms	(1R)-1-[(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-2,2,2-trifluoroethyl 2,6-difluorobenzoate; (1R)-1-(1,4-Dioxa-8-azaspiro[4.5]dec-8-ylmethyl)-2,2,2-trifluoroethyl 2,6-difluorobenzoate; 2,6-Difluorobenzoic Acid (1R)-1-(1,4-Dioxa-8-azaspiro[4.5]dec-8-ylmethyl)-2,2,2-trifluoroethyl Ester; (1R)-1-(1,4-Dioxa-8-azaspiro[4.5]dec-8-ylmethyl)-2,2,2-trifluoroethyl 2,6-difluorobenzoate; CAS 477762-58-6; 8-{[(1R)-2,2,2-Trifluoro-1-(2,6-difluorobenzoyloxy)ethyl]methyl}-1,4-dioxa-8-azaspiro[4.5]decane; Trifluoroethyl 2,6-difluorobenzoate spirocyclic derivative
EINECS	Contact for details

Quality Control

Our (1R)-1-(1,4-Dioxa-8-Azaspiro[4.5]Dec-8-Ylmethyl)-2,2,2-Trifluoroethyl 2,6-Difluorobenzenecarboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. All products undergo rigorous analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is stable under these conditions but should be kept away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area Percent)
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.