Description

Ethyl 3-Amino-4-(Trifluoromethyl)-6-(4-Fluorophenyl)Furo[2,3-B]Pyridine-2-Carboxylate is a high-value, multi-functional heterocyclic building block critical for advanced organic synthesis. Its complex fused-ring structure, featuring both furopyridine and trifluoromethyl motifs, makes it a key intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures with enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold in the synthesis of potential drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Research: Used to develop new generations of herbicides, fungicides, and insecticides, leveraging the stability imparted by the fluorine and trifluoromethyl groups.
• Material Science Precursor: Acts as a building block for advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a fluorescent tag or probe due to its fused aromatic system.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	Ethyl 3-Amino-4-(Trifluoromethyl)-6-(4-Fluorophenyl)Furo[2,3-B]Pyridine-2-Carboxylate
CAS No.	477320-36-8
Molecular Formula	C₁₇H₁₂F₄N₂O₃
Molecular Weight	368.29 g/mol
Synonyms	Ethyl 3-Amino-4-(trifluoromethyl)-6-(4-fluorophenyl)furo[2,3-b]pyridine-2-carboxylate; 3-Amino-4-(trifluoromethyl)-6-(4-fluorophenyl)furo[2,3-b]pyridine-2-carboxylic acid ethyl ester; Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-4-(trifluoromethyl)-6-(4-fluorophenyl)-, ethyl ester; CAS 477320-36-8; 6-(4-Fluorophenyl)-4-(trifluoromethyl)furo[2,3-b]pyridine-2-carboxylic acid ethyl ester, 3-amino-; Ethyl 3-amino-4-trifluoromethyl-6-(p-fluorophenyl)furo[2,3-b]pyridine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 3-Amino-4-(Trifluoromethyl)-6-(4-Fluorophenyl)Furo[2,3-B]Pyridine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF for moisture content, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.