Description

3-Chloromethyl-Pyrrolidine-1-Carboxylic Acid Benzyl Ester is a versatile and high-purity chemical building block essential for advanced organic synthesis. This compound is valued for its reactive chloromethyl group and protected amine functionality, enabling precise molecular construction. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of piperidine and pyrrolidine-based drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Protease Inhibitor Development: Serves as a crucial precursor in the construction of pharmacophores for protease inhibitors, including those targeting viral and cardiovascular diseases.
• Ligand and Catalyst Synthesis: Used to prepare chiral ligands and organocatalysts for asymmetric synthesis applications.
• Peptidomimetic Chemistry: Facilitates the creation of peptidomimetic scaffolds by introducing constrained pyrrolidine rings into peptide backbones.
• Agrochemical Research: Employed in the research and development of novel herbicides and fungicides with complex heterocyclic structures.
• Material Science: Acts as a monomer or cross-linking agent in the synthesis of specialized polymers and functional materials.

Basic Information

Product Name	3-Chloromethyl-Pyrrolidine-1-Carboxylic Acid Benzyl Ester
CAS No.	476474-01-8
Molecular Formula	C14H18ClNO2
Molecular Weight	267.75 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-(chloromethyl)pyrrolidine; 3-(Chloromethyl)-1-[(phenylmethoxy)carbonyl]pyrrolidine; 3-(Chloromethyl)pyrrolidine-1-carboxylic acid benzyl ester; Benzyl 3-(chloromethyl)pyrrolidine-1-carboxylate; 1-CBZ-3-chloromethylpyrrolidine; 1-N-Cbz-3-chloromethylpyrrolidine; (3-Chloromethyl-pyrrolidin-1-yl)-carboxylic acid benzyl ester
EINECS	Contact for details

Quality Control

Our 3-Chloromethyl-Pyrrolidine-1-Carboxylic Acid Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.