Description

L-Valine, 3-Methyl-n-(2,2,2-Trichloroacetyl)-, Methyl Ester is a specialized chiral building block and protected amino acid derivative of significant interest in advanced organic synthesis. Its core value lies in providing a stereochemically defined valine scaffold with orthogonal protecting groups, enabling precise and complex molecular construction. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and bioactive molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate modified valine residues with specific side-chain protection.
• Proteomics & Biochemical Research: Serves as a precursor for designing enzyme inhibitors, receptor ligands, and molecular probes to study biological pathways.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions due to its defined stereocenter.
• Agrochemical Research: Potential use in the synthesis of chiral active ingredients for crop protection products.

Basic Information

Product Name	L-Valine, 3-Methyl-n-(2,2,2-Trichloroacetyl)-, Methyl Ester
CAS No.	475586-45-9
Molecular Formula	C9H14Cl3NO3
Molecular Weight	306.57 g/mol
Synonyms	Methyl N-(2,2,2-trichloroacetyl)-L-valinate; L-Valine, N-(trichloroacetyl)-, methyl ester; (S)-Methyl 2-((2,2,2-trichloroacetyl)amino)-3-methylbutanoate; N-Trichloroacetyl-L-valine methyl ester; Methyl N-trichloroacetyl-L-valinate; Trichloroacetyl-L-valine methyl ester; (S)-Methyl 2-(2,2,2-trichloroacetamido)-3-methylbutanoate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development. Each lot is characterized using advanced analytical techniques, including HPLC, GC, NMR, and chiral analysis, to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.