Description

(E)-3-Bromo-2-tert-Butoxycarbonylamino-But-2-Enoic Acid Methyl Ester is a high-value, protected amino acid derivative and a crucial chiral building block in advanced organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on peptide mimetics, protease inhibitors, and other bioactive compounds requiring stereochemical control.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in the development of protease inhibitors and peptidomimetics.
• Peptide Chemistry: Used in the preparation of non-natural amino acid residues for solid-phase and solution-phase peptide synthesis to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a critical scaffold in drug discovery programs for generating focused libraries and exploring structure-activity relationships (SAR).
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for candidate drugs during development phases.
• Chemical Biology: Utilized in the synthesis of molecular probes and labeled compounds for studying biological pathways and enzyme mechanisms.

Basic Information

Product Name	(E)-3-Bromo-2-tert-Butoxycarbonylamino-But-2-Enoic Acid Methyl Ester
CAS No.	475288-42-7
Molecular Formula	C11H18BrNO4
Molecular Weight	308.17 g/mol
Synonyms	Methyl (2E)-3-bromo-2-[[(tert-butoxy)carbonyl]amino]but-2-enoate; (E)-Methyl 3-bromo-2-((tert-butoxycarbonyl)amino)but-2-enoate; Boc-Abv(Br)-OMe; N-Boc-3-bromo-dehydroaminobutyric acid methyl ester; (E)-3-Bromo-2-(Boc-amino)but-2-enoic acid methyl ester; 2-Butenoic acid, 3-bromo-2-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester, (2E)-; Methyl (E)-3-bromo-2-(tert-butoxycarbonylamino)but-2-enoate
EINECS	Contact for details

Quality Control

Our (E)-3-Bromo-2-tert-Butoxycarbonylamino-But-2-Enoic Acid Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of pharmaceutical R&D. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support regulatory filings, and we can supply material compliant with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.