Description

Spiro[Furo[3,4-B]Pyridine-5(7H),4'-Piperidin]-7-One Hydrochloride CAS NO 475152-31-9 is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and heterocyclic structure. This compound is of significant value for research and development in medicinal chemistry, particularly for its potential as a key building block in novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in the synthesis of new therapeutic agents targeting central nervous system (CNS) disorders and other complex diseases.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, particularly those with spirocyclic architectures.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Integral to the development and scale-up processes for new Active Pharmaceutical Ingredients (APIs), especially in neurological and psychiatric therapeutic areas.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and process development projects.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis methodology development and pharmacological studies.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	Spiro[Furo[3,4-B]Pyridine-5(7H),4'-Piperidin]-7-One Hydrochloride
CAS No.	475152-31-9
Molecular Formula	C12H14N2O2·HCl
Molecular Weight	254.71 g/mol
Synonyms	7-Oxospiro[furo[3,4-b]pyridine-5(7H),4'-piperidine] hydrochloride; Spiro(furo[3,4-b]pyridine-5,4'-piperidin)-7-one hydrochloride; 1',2',3',4',5',7'-Hexahydrospiro[piperidine-4,5'-furo[3,4-b]pyridin]-7'-one hydrochloride; 475152-31-9; Spiro[furo[3,4-b]pyridine-5(7H),4'-piperidin]-7-one HCl
EINECS	Contact for details

Quality Control

Our Spiro[Furo[3,4-B]Pyridine-5(7H),4'-Piperidin]-7-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure compliance with pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and consistency for your critical R&D and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.