Description

1-Boc-5-Chloro-2-Trimethylsilanyl-Indole is a versatile and high-purity protected indole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the dual protection of the indole nitrogen and the 2-position, enabling selective functionalization for the construction of complex heterocyclic systems. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indole-based drug candidates, including kinase inhibitors and serotonin receptor modulators.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that leverage the indole scaffold.
• Material Science: Serves as a precursor for functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other electronic materials.
• Academic & R&D: A valuable reagent for methodological studies in cross-coupling reactions, C-H functionalization, and total synthesis of natural products.
• Fine Chemical Synthesis: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	1-Boc-5-Chloro-2-Trimethylsilanyl-Indole
CAS No.	475102-16-0
Molecular Formula	C₁₆H₂₂ClNO₂Si
Molecular Weight	323.89 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-5-chloro-2-(trimethylsilyl)-1H-indole; 5-Chloro-2-(trimethylsilyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 5-chloro-2-(trimethylsilyl)-1H-indole-1-carboxylate; 1-Boc-5-chloro-2-TMS-indole; 5-Chloro-2-trimethylsilyl-1H-indole-1-carboxylic acid tert-butyl ester; Boc-5-Cl-2-TMS-indole; 475102-16-0
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Chloro-2-Trimethylsilanyl-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring reliable and consistent performance in sensitive synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.