Description

5-Bromo-1-(tert-Butoxycarbonyl)-1H-Indol-2-Ylboronic Acid is a high-value, multi-functional boronic acid derivative designed for advanced synthetic chemistry. This compound is a critical building block in modern pharmaceutical research and development, enabling the precise construction of complex molecular architectures. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications requiring high-purity intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic acid coupling partner for the formation of carbon-carbon bonds, essential for constructing complex heterocyclic systems.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Synthesis: Employed in the research and development of new active ingredients for crop protection products.
• Chemical Biology Probes: Useful for the synthesis of molecular probes to study biological pathways and protein functions.
• Advanced Materials Development: Potential building block for creating organic electronic materials and functional polymers.

Basic Information

Product Name	5-Bromo-1-(tert-Butoxycarbonyl)-1H-Indol-2-Ylboronic Acid
CAS No.	475102-13-7
Molecular Formula	C₁₃H₁₅BBrNO₄
Molecular Weight	340.98 g/mol
Synonyms	5-Bromo-1-Boc-indole-2-boronic acid; 2-Borono-5-bromo-1-[(tert-butoxy)carbonyl]-1H-indole; 1-Boc-5-bromoindole-2-boronic acid; 5-Bromo-1-(Boc)-1H-indole-2-boronic acid; 5-Bromo-1-N-Boc-indole-2-boronic acid; tert-Butyl 5-bromo-2-borono-1H-indole-1-carboxylate; B-5-Bromo-1-(tert-butoxycarbonyl)-1H-indol-2-yl-boronic acid
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(tert-Butoxycarbonyl)-1H-Indol-2-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.