Description

1-Boc-5-Chloro-1H-Indole-2-Boronic Acid is a high-purity, protected indole boronic acid derivative, serving as a critical building block in modern synthetic organic chemistry. Its value lies in enabling precise cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those containing indole or heterocyclic scaffolds.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functionality enables efficient carbon-carbon bond formation with aryl or vinyl halides, a cornerstone reaction in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific indole-based structures.
• Material Science: Potential building block for creating organic electronic materials and functional polymers.
• Academic & R&D: A valuable reagent for methodological development and exploring new synthetic pathways in university and corporate research laboratories.
• Scale-up Synthesis: Suitable for process development and pilot-scale production of target molecules due to its defined reactivity and stability when protected.

Basic Information

Product Name	1-Boc-5-Chloro-1H-Indole-2-Boronic Acid
CAS No.	475102-12-6
Molecular Formula	C₁₃H₁₅BClNO₄
Molecular Weight	295.52 g/mol
Synonyms	5-Chloro-1H-indole-2-boronic acid, 1-(1,1-dimethylethyl) ester; 1-Boc-5-chloroindole-2-boronic acid; tert-Butyl 5-chloro-2-borono-1H-indole-1-carboxylate; 5-Chloro-1-[(tert-butoxy)carbonyl]-1H-indole-2-boronic acid; 1-Boc-5-Cl-indole-2-BA; Boc-5-Chloroindole-2-boronic Acid; (1-((tert-Butoxycarbonyl)-5-chloro-1H-indol-2-yl)boronic acid
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Chloro-1H-Indole-2-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for critical cross-coupling applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.