Description

tert-Butyl 2-(4-Hydroxybutoxy)Acetate is a high-purity chemical intermediate featuring a unique bifunctional structure that combines a protected carboxylic acid group with a terminal hydroxyl group. This molecular architecture makes it a versatile and valuable building block for the controlled synthesis of complex molecules, particularly in advanced pharmaceutical and fine chemical manufacturing. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries who require precise and reliable synthetic intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for prodrug development and linker chemistry in antibody-drug conjugates (ADCs).
• Polymer Modification: Used to introduce functional side chains or cross-linking sites into specialty polymers, enhancing properties like hydrophilicity or biodegradability.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and plant growth regulators requiring specific ether and ester functionalities.
• Liquid Crystal & Electronic Materials: Employed in the production of monomers for functional materials where controlled chain length and terminal reactivity are critical.
• Cross-linking Agent: Acts as a difunctional monomer in formulations for coatings, adhesives, and sealants that cure under specific conditions.
• Organic Synthesis Reagent: Provides a convenient source of a protected glycolic acid derivative for multi-step synthetic routes in academic and industrial research laboratories.

Basic Information

Product Name	tert-Butyl 2-(4-Hydroxybutoxy)Acetate
CAS No.	475086-57-8
Molecular Formula	C10H20O4
Molecular Weight	204.26 g/mol
Synonyms	2-(4-Hydroxybutoxy)acetic acid tert-butyl ester; Acetic acid, 2-(4-hydroxybutoxy)-, 1,1-dimethylethyl ester; tert-Butyl glycolic acid 4-hydroxybutyl ether; 4-Hydroxybutyl glycolate tert-butyl ether; tert-Butyl (2-(4-hydroxybutoxy)acetate); TBHBA; Glycolic acid tert-butyl ester 4-hydroxybutyl ether
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 2-(4-Hydroxybutoxy)Acetate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation (if applicable)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.