Description

tert-Butyl-Dimethyl-[[(2R)-Pyrrolidin-2-Yl]Methoxy]Silane is a specialized organosilicon compound featuring a chiral pyrrolidine moiety, making it a valuable building block in asymmetric synthesis. This compound is critical for researchers and manufacturers requiring high-purity, stereochemically defined intermediates for advanced pharmaceutical development. It is primarily utilized in the synthesis of active pharmaceutical ingredients (APIs), particularly in the creation of complex molecules where the (2R)-pyrrolidin-2-yl group is a key pharmacophore.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Asymmetric Catalysis: Used as a precursor or ligand for chiral catalysts in stereoselective chemical transformations.
• Peptidomimetics & Proline Derivatives: Serves as a protected proline analog for constructing peptide-like molecules with enhanced metabolic stability.
• Chemical Biology Probes: Employed in the development of labeled compounds and probes for studying biological mechanisms.
• Agrochemical Synthesis: Utilized in the creation of advanced, enantiomerically pure agrochemicals.
• Material Science Research: Acts as a functional silane for surface modification or as a monomer for specialized polymers.

Basic Information

Product Name	tert-Butyl-Dimethyl-[[(2R)-Pyrrolidin-2-Yl]Methoxy]Silane
CAS No.	474774-33-9
Molecular Formula	C11H25NOSi
Molecular Weight	215.41 g/mol
Synonyms	(R)-tert-Butyldimethyl((pyrrolidin-2-yl)methoxy)silane; (2R)-2-[[(tert-Butyldimethylsilyl)oxy]methyl]pyrrolidine; (R)-2-((tert-Butyldimethylsilyloxy)methyl)pyrrolidine; (R)-N-Boc-2-((tert-butyldimethylsilyloxy)methyl)pyrrolidine (protected form); (R)-Pyrrolidin-2-ylmethanol tert-butyldimethylsilyl ether; TBDMS-(R)-Prolinol; (R)-TBDMS-Prolinol; (R)-2-(Hydroxymethyl)pyrrolidine TBDMS ether
EINECS	Contact for details

Quality Control

Our tert-Butyl-Dimethyl-[[(2R)-Pyrrolidin-2-Yl]Methoxy]Silane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for pharmaceutical R&D and cGMP intermediate production. Certificates of Analysis (COA) detailing identity, purity (by HPLC/GC), chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.