Description

Pentafluoro[(Triisopropylsilyl)Ethynyl]Sulfur is a specialized organofluorine and organosilicon reagent featuring a unique pentafluorosulfur (SF5) group linked to a protected acetylene moiety. This compound matters as a high-value building block for introducing the highly electronegative and lipophilic SF5 group into complex molecules, a modification sought after for tuning physicochemical properties in advanced materials and pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and materials science industries for creating novel compounds with enhanced stability, bioavailability, and performance.

Application

• Pharmaceutical Intermediate: Used in the synthesis of bioactive molecules where the SF5 group can improve metabolic stability and membrane permeability.
• Agrochemical Research: Serves as a key precursor for developing new generation pesticides and herbicides with novel modes of action.
• Advanced Material Synthesis: Incorporated into liquid crystals, organic semiconductors, and polymers to modify electronic properties and thermal stability.
• Fluorine Chemistry & Catalysis: Acts as a versatile reagent in organofluorine chemistry for constructing complex fluorinated architectures.
• Radiopharmaceutical Labeling: Potential use in the development of PET (Positron Emission Tomography) tracers utilizing fluorine-18, given the presence of multiple fluorine atoms.
• Ligand and Catalyst Design: The ethynyl group allows for further functionalization via click chemistry, useful in creating specialized ligands.

Basic Information

Product Name	Pentafluoro[(Triisopropylsilyl)Ethynyl]Sulfur
CAS No.	474668-34-3
Molecular Formula	C11H19F5SSi
Molecular Weight	306.40 g/mol
Synonyms	(Triisopropylsilyl)ethynylsulfur pentafluoride; SF5-C≡C-Si(i-Pr)3; Ethynyltriisopropylsilane, pentafluoro sulfur adduct; 1-(Pentafluoro-λ6-sulfanyl)-2-(triisopropylsilyl)ethyne; Pentafluoro(2-triisopropylsilylethynyl)sulfur
EINECS	Contact for details

Quality Control

Our production of Pentafluoro[(Triisopropylsilyl)Ethynyl]Sulfur adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized by advanced analytical techniques including NMR (1H, 13C, 19F) and GC/HPLC to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place, ideally at 2-8°C (refrigerated) or as specified on the label to mitigate its highly volatile nature. Keep away from heat, sparks, and open flames. Containers should be kept tightly sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
1H NMR	Conforms
19F NMR	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.