Description

(βs)-β-[(1,1-tert-Dimethylethoxycarbonyl)Amino]-4-Hydroxy-Benzenepropanoic Acid Methyl Ester is a high-purity, protected amino acid derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex peptide and small molecule targets, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel therapeutic agents, including protease inhibitors and other bioactive peptides.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in the discovery and structure-activity relationship (SAR) studies of new therapeutic compounds.
• Peptide Synthesis: Serves as a protected tyrosine derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for complex organic molecules.
• Bioconjugation: Potential use in the development of antibody-drug conjugates (ADCs) and other targeted therapies.
• Chemical Biology Probes: Useful for creating labeled or modified peptides to study biological pathways and protein interactions.

Basic Information

Item	Details
Product Name	(βs)-β-[(1,1-tert-Dimethylethoxycarbonyl)Amino]-4-Hydroxy-Benzenepropanoic Acid Methyl Ester
CAS No.	474295-85-7
Molecular Formula	C16H23NO6
Molecular Weight	325.36 g/mol
Synonyms	Boc-Tyr(Me)-OH; Methyl (2S)-3-(4-hydroxyphenyl)-2-{[(2-methylpropan-2-yl)oxycarbonyl]amino}propanoate; N-Boc-O-methyl-L-tyrosine; Boc-L-Tyrosine methyl ester; Boc-Tyr-OMe; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-hydroxyphenyl)propanoic acid methyl ester; N-tert-Butoxycarbonyl-L-tyrosine methyl ester
EINECS	Contact for details

Quality Control

Our production of (βs)-β-[(1,1-tert-Dimethylethoxycarbonyl)Amino]-4-Hydroxy-Benzenepropanoic Acid Methyl Ester adheres to stringent quality management protocols. Each batch is analyzed using advanced techniques like HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.