Description

5-(tert-Butoxycarbonylamino-Methyl)-Nicotinic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical building block in the development of complex molecules, offering a reactive carboxylic acid group and a Boc-protected amine for selective deprotection. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for constructing active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Mimetics & Conjugates: Used to incorporate nicotinic acid scaffolds into peptide chains for creating novel bioconjugates and mimetics.
• Chemical Biology Probes: Serves as a precursor for labeling reagents and molecular probes used in biochemical research.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Acts as an intermediate in the development of new crop protection agents and herbicides.
• Academic & Contract Research: A valuable reagent for methodology development and exploratory synthesis in academic and CRO laboratories.

Basic Information

Product Name	5-(tert-Butoxycarbonylamino-Methyl)-Nicotinic Acid
CAS No.	473924-59-3
Molecular Formula	C12H16N2O4
Molecular Weight	252.27 g/mol
Synonyms	5-[(tert-Butoxycarbonylamino)methyl]pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-; Boc-AMNA; 5-(Boc-aminomethyl)nicotinic acid; N-Boc-3-carboxy-5-aminomethylpyridine; 5-(N-Boc-aminomethyl)nicotinic Acid; tert-Butyl N-[(5-carboxypyridin-3-yl)methyl]carbamate
EINECS	Contact for details

Quality Control

Every batch of 5-(tert-Butoxycarbonylamino-Methyl)-Nicotinic Acid is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.