Description

Pyridine, 4-Chloro-3,5-Bis(Trimethylsilyl)- (9Ci) is a highly functionalized organosilicon pyridine derivative, serving as a valuable and versatile building block in advanced organic synthesis. Its unique structure, featuring both a chloro substituent and two trimethylsilyl (TMS) protecting groups, makes it a critical intermediate for constructing complex molecules with precise regiochemistry. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of novel drug candidates, particularly in medicinal chemistry programs targeting heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the pyridine core is a common bioactive motif.
• Ligand Precursor: Serves as a starting material for the synthesis of specialized nitrogen-containing ligands used in catalysis and material science.
• Organic Electronics: Potential building block for the creation of novel organic semiconductors and charge-transport materials due to its functionalized aromatic system.
• Chemical Research: Employed in academic and industrial R&D for method development, such as in cross-coupling reactions and silylation chemistry.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals and flavors/fragrances.

Basic Information

Product Name	Pyridine, 4-Chloro-3,5-Bis(Trimethylsilyl)- (9Ci)
CAS No.	473807-28-2
Molecular Formula	C11H20ClNSi2
Molecular Weight	245.91 g/mol
Synonyms	4-Chloro-3,5-bis(trimethylsilyl)pyridine; 3,5-Bis(trimethylsilyl)-4-chloropyridine; 4-Chloro-3,5-di(trimethylsilyl)pyridine; Pyridine, 4-chloro-3,5-bis(trimethylsilyl)-; 4-Chloro-3,5-bis(trimethylsilyl)pyridine (9CI); 4-Chloro-3,5-di-TMS-pyridine
EINECS	Contact for details

Quality Control

Our production of Pyridine, 4-Chloro-3,5-Bis(Trimethylsilyl)- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including NMR, HPLC, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We are committed to supplying material that meets the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.