Description

Amg 487 CAS NO 473719-41-4 is a high-purity, small molecule chemical compound primarily utilized in advanced pharmaceutical research and development. This compound is valued for its role as a selective and potent CXCR3 chemokine receptor antagonist, making it a critical tool for investigating inflammatory and autoimmune pathways. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors focused on novel therapeutic discovery.

Application

• Pharmaceutical Research: Acts as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of new drugs targeting inflammatory diseases.
• Biochemical Assays: Used as a selective CXCR3 antagonist in in vitro and in vivo studies to elucidate immune cell migration and function.
• Autoimmune Disease Research: A vital compound for investigating potential treatments for conditions like rheumatoid arthritis, multiple sclerosis, and psoriasis.
• Oncology Research: Employed in studies exploring the role of chemokine receptors in tumor microenvironment and cancer metastasis.
• Academic & Institutional R&D: Serves as a critical reagent in university and institutional laboratories for fundamental immunological research.
• Contract Research Organizations (CROs): Supplied to CROs conducting preclinical efficacy and safety testing for client drug discovery programs.

Basic Information

Product Name	Amg 487
CAS No.	473719-41-4
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	NBI-74330; 1-Naphthalenecarboxamide, N-(2-((4-((2,4-difluorophenyl)methyl)-1-piperazinyl)carbonyl)phenyl)-; AMG-487; CXCR3 Antagonist AMG487; (R)-N-(2-(4-(2,4-Difluorobenzyl)piperazine-1-carbonyl)phenyl)-1-naphthamide; GSK-1325756 (discontinued development name); Potent CXCR3 antagonist
EINECS	Contact for details

Quality Control

Our Amg 487 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass)	Conforms (M+1: 365.2)
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.