Description

5-Bromo-2-Fluoro-3-Phenylpyridine is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique molecular architecture, which enables the precise introduction of bromine and fluorine substituents onto a phenylpyridine scaffold, a key step in modulating the biological activity and physicochemical properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly in medicinal chemistry for creating kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially for targeted cancer therapies and kinase inhibitors.
• Agrochemical Synthesis: Used in creating advanced active ingredients for crop protection products, leveraging the fluorine atom for enhanced metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for synthesizing functionalized ligands and organic electronic materials due to its conjugated system and halogen handles.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorinated Compound Libraries: A valuable building block for combinatorial chemistry and the generation of diverse fluorinated compound libraries for high-throughput screening.

Basic Information

Product Name	5-Bromo-2-Fluoro-3-Phenylpyridine
CAS No.	473596-03-1
Molecular Formula	C11H7BrFN
Molecular Weight	252.08 g/mol
Synonyms	3-Phenyl-5-bromo-2-fluoropyridine; 2-Fluoro-5-bromo-3-phenylpyridine; 5-Bromo-2-fluoro-3-phenylpyridine; 473596-03-1; Pyridine, 5-bromo-2-fluoro-3-phenyl-; 3-Phenyl-2-fluoro-5-bromopyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Fluoro-3-Phenylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and GC-MS for identity and impurity profiling, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.