Description

(E)-4-Chloronicotinaldehyde Oxime is a high-purity, versatile organic intermediate characterized by its specific oxime and chloropyridine functional groups. This compound is critical for facilitating complex synthetic transformations in advanced pharmaceutical and agrochemical research and development. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Serves as a precursor in the development of new generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the chloronicotinate scaffold.
• Ligand and Catalyst Development: Used in academic and industrial research to create novel chelating ligands for metal-catalyzed cross-coupling and asymmetric synthesis reactions.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.

Basic Information

Product Name	(E)-4-Chloronicotinaldehyde Oxime
CAS No.	471909-43-0
Molecular Formula	C6H5ClN2O
Molecular Weight	156.57 g/mol
Synonyms	4-Chloropyridine-3-carboxaldehyde oxime; (E)-4-Chloronicotinaldoxime; 4-Chloro-3-pyridinecarboxaldehyde oxime; 4-Chloronicotinaldehyde oxime; 3-Pyridinecarboxaldehyde, 4-chloro-, oxime; (E)-4-Chloro-3-pyridinecarboxaldehyde oxime; 4-Chloronicotinaldoxime (E-isomer); 4-Chloro-3-formylpyridine oxime
EINECS	Contact for details

Quality Control

Every batch of (E)-4-Chloronicotinaldehyde Oxime is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency meet the exacting standards required for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, isomeric ratio, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (E-isomer)	≥ 98.0% (by HPLC)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.