Description

4',5-Di-o-Acetyl-7-o-tert-Butyldimethylsilyl Genistein is a key protected derivative of the natural isoflavone genistein, designed for advanced synthetic chemistry applications. This compound is critically important as a versatile synthetic intermediate, enabling the precise construction of complex molecules for pharmaceutical and biochemical research. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in oncology, endocrinology, and as a building block for targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a crucial protected precursor in the multi-step synthesis of novel genistein analogs and other bioactive isoflavonoids for drug discovery programs.
• Biochemical Research: Used in studies investigating structure-activity relationships (SAR) of isoflavones, where selective deprotection allows for functional group manipulation.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and impurity profiling of related compounds.
• Prodrug Development: Acts as a starting material for designing prodrugs with improved bioavailability and targeted release profiles of the active genistein moiety.
• Chemical Biology Probes: Utilized in the synthesis of labeled or tagged molecular probes to study estrogen receptor interactions and other biological pathways.
• Academic & Industrial R&D: Fundamental building block in organic chemistry research for developing new synthetic methodologies involving silyl and acetyl protecting groups.

Basic Information

Product Name	4',5-Di-o-Acetyl-7-o-tert-Butyldimethylsilyl Genistein
CAS No.	470666-99-0
Molecular Formula	C27H32O7Si
Molecular Weight	496.63 g/mol
Synonyms	7-[(tert-Butyldimethylsilyl)oxy]-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 4',5-Diacetate; 4',5-Di-O-acetyl-7-O-(tert-butyldimethylsilyl)genistein; TBDMS-protected Genistein Diacetate; Genistein 4',5-Diacetate 7-TBDMS Ether; 7-O-tert-Butyldimethylsilyl-4',5-di-O-acetylgenistein; 4',5-Diacetyl-7-tert-butyldimethylsilyl Genistein; BTM-1092 (Research Code); Protected Genistein Derivative
EINECS	Contact for details

Quality Control

Our 4',5-Di-o-Acetyl-7-o-tert-Butyldimethylsilyl Genistein is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure compliance with research-grade specifications. Comprehensive Certificates of Analysis (COA) detailing all test results are provided to guarantee traceability and batch-to-batch consistency for your critical research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Keep away from incompatible materials such as fluorides and strong alkalis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.