Description

2-Chloro-4-Trimethylsilanylethynyl-Nicotinic Acid Methyl Ester is a high-value, functionalized pyridine derivative designed for advanced synthetic chemistry. This compound is a critical building block for the development of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting kinase inhibition or other protein-ligand interactions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogen and alkyne functionalities.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probe Synthesis: The ethynyl group enables efficient conjugation via click chemistry (e.g., CuAAC) for labeling and bioconjugation applications.
• Ligand and Catalyst Development: Utilized in the preparation of complex ligands for transition metal catalysis and organometallic chemistry.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring this specific molecular architecture.

Basic Information

Product Name	2-Chloro-4-Trimethylsilanylethynyl-Nicotinic Acid Methyl Ester
CAS No.	470463-44-6
Molecular Formula	C12H14ClNO2Si
Molecular Weight	267.78 g/mol
Synonyms	Methyl 2-chloro-4-((trimethylsilyl)ethynyl)nicotinate; 2-Chloro-4-((trimethylsilyl)ethynyl)nicotinic acid methyl ester; 2-Chloro-4-(trimethylsilylethynyl)nicotinic acid methyl ester; 2-Chloro-4-(trimethylsilylethynyl)pyridine-3-carboxylic acid methyl ester; 3-Pyridinecarboxylic acid, 2-chloro-4-[(trimethylsilyl)ethynyl]-, methyl ester; Methyl 2-chloro-4-(trimethylsilylethynyl)nicotinate; 470463-44-6
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-4-Trimethylsilanylethynyl-Nicotinic Acid Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by modern analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.