Description

2,2-Dimethyl-n-(5-Trimethylsilanylethynyl-Pyridin-2-Yl)-Propionamide is a specialized organosilicon compound featuring a pyridine core and a terminal alkyne protected by a trimethylsilyl (TMS) group. This unique structure makes it a versatile and valuable building block in advanced organic synthesis, particularly for applications requiring precise molecular architecture. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of new active ingredients and complex functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting neurological and oncological pathways.
• Ligand Synthesis: Used to construct sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced polymers and silicon-based hybrid materials.
• Click Chemistry: The TMS-protected alkyne moiety can be deprotected to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
• Agrochemical Development: Employed in the research and synthesis of new-generation crop protection agents.
• Chemical Biology Probes: Useful for labeling and studying biological systems due to its modifiable functional groups.

Basic Information

Product Name	2,2-Dimethyl-n-(5-Trimethylsilanylethynyl-Pyridin-2-Yl)-Propionamide
CAS No.	470463-43-5
Molecular Formula	C15H22N2OSi
Molecular Weight	274.44 g/mol
Synonyms	N-(5-((Trimethylsilyl)ethynyl)pyridin-2-yl)-2,2-dimethylpropanamide; 2,2-Dimethyl-N-[5-(2-trimethylsilylethynyl)-2-pyridyl]propanamide; 5-Trimethylsilylethynyl-2-pivalamidopyridine; Propanamide, 2,2-dimethyl-N-[5-[(trimethylsilyl)ethynyl]-2-pyridinyl]-; TMS-Ethynyl Pyridine Pivalamide Derivative
EINECS	Contact for details

Quality Control

Our high-purity 2,2-Dimethyl-n-(5-Trimethylsilanylethynyl-Pyridin-2-Yl)-Propionamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.