Description

(5-Trimethylsilanylethynyl-Pyridin-2-Yl)-Carbamic Acid tert-Butyl Ester is a specialized organosilicon-protected pyridine derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its primary value lies in its role as a protected building block for constructing complex molecular architectures, particularly in pharmaceutical discovery and materials science. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, functionalized intermediates for coupling reactions and target molecule synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel crop protection agents and herbicides requiring specific pyridine-based scaffolds.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of advanced polymers, ligands for catalysis, and organic electronic materials.
• Cross-Coupling Reactions: The ethynyl and silyl protecting groups make it a valuable substrate for Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological systems due to its modifiable functional groups.
• Academic & R&D: A valuable reagent for methodological development and exploratory synthesis in university and corporate research laboratories.

Basic Information

Item	Details
Product Name	(5-Trimethylsilanylethynyl-Pyridin-2-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	470463-41-3
Molecular Formula	C15H22N2O2Si
Molecular Weight	290.44 g/mol
Synonyms	tert-Butyl N-[5-[(trimethylsilyl)ethynyl]-2-pyridyl]carbamate; N-Boc-5-((trimethylsilyl)ethynyl)pyridin-2-amine; 5-((Trimethylsilyl)ethynyl)pyridin-2-amine, N-Boc protected; 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-[(trimethylsilyl)ethynyl]pyridine; Boc-5-TMS-ethynyl-2-aminopyridine; 5-(Trimethylsilylethynyl)pyridin-2-yl-carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (5-Trimethylsilanylethynyl-Pyridin-2-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from incompatible materials such as strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.