Description

2-Chloro-3-Trimethylsilanylethynyl-Pyridine is a specialized organosilicon building block featuring a pyridine core functionalized with both chloro and trimethylsilylethynyl groups. This compound is a high-value intermediate prized for its role in cross-coupling reactions, particularly Sonogashira couplings, enabling the modular synthesis of complex molecular architectures. It is essential for researchers and process chemists in the pharmaceutical and advanced materials sectors who require precise, functionalized heterocycles for drug discovery and organic electronic applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring functionalized pyridine scaffolds.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its conjugated ethynyl group.
• Agrochemical Synthesis: Serves as a precursor for creating novel herbicides and insecticides with pyridine-based structures.
• Cross-Coupling Reactions: Primarily employed in Sonogashira coupling reactions to form carbon-carbon bonds, constructing complex alkynyl-substituted heterocycles.
• Ligand and Catalyst Preparation: Utilized for synthesizing novel ligands for transition metal catalysis.
• Chemical Biology Probes: Acts as a starting material for creating tagged molecules used in biochemical assays and imaging.

Basic Information

Product Name	2-Chloro-3-Trimethylsilanylethynyl-Pyridine
CAS No.	470463-35-5
Molecular Formula	C11H14ClNSi
Molecular Weight	223.77 g/mol
Synonyms	2-Chloro-3-((trimethylsilyl)ethynyl)pyridine; 3-((Trimethylsilyl)ethynyl)-2-chloropyridine; 2-Chloro-3-(trimethylsilylethynyl)pyridine; 2-Chloro-3-(trimethylsilylethinyl)pyridine; 2-Chloro-3-(trimethylsilyl)ethynylpyridine; Pyridine, 2-chloro-3-[(trimethylsilyl)ethynyl]-; TMS-Ethynyl-2-Chloropyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Trimethylsilanylethynyl-Pyridine is manufactured and analyzed under strict quality management protocols. We ensure high purity and consistency through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.