Description

1,4,7,10-Tetraazacyclododecane-1-Acetic Acid,Ethyl Ester is a key macrocyclic intermediate, specifically a functionalized cyclen derivative, essential for advanced coordination chemistry. Its primary value lies in its role as a versatile precursor for synthesizing sophisticated chelating agents and bifunctional coupling ligands used in diagnostic and therapeutic applications. This high-purity building block is critically needed by research institutions and manufacturers in the pharmaceutical, biomedical imaging, and radiopharmaceutical sectors for developing novel metal complexes.

Application

• Precursor for synthesizing DOTA (1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid) and its monoamide (DOTAGA) derivatives.
• Key intermediate in the production of bifunctional chelators for labeling peptides, antibodies, and other biomolecules with diagnostic or therapeutic radionuclides (e.g., 68Ga, 177Lu, 90Y).
• Building block for advanced MRI contrast agent research and development.
• Starting material for creating customized macrocyclic ligands with specific binding properties for lanthanide and actinide ions.
• Used in academic and industrial research focused on supramolecular chemistry and catalysis.
• Essential for developing targeted radiopharmaceuticals for cancer diagnosis (PET/SPECT imaging) and therapy (radioligand therapy).

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1-Acetic Acid,Ethyl Ester
CAS No.	468743-81-9
Molecular Formula	C14H28N4O2
Molecular Weight	284.40 g/mol
Synonyms	1,4,7,10-Tetraazacyclododecane-1-acetic acid ethyl ester; Ethyl-DO3A; Monoethyl-DOTA; 1-Carboxyethyl-1,4,7,10-tetraazacyclododecane; Cyclen-1-acetic acid ethyl ester; 1,4,7,10-Tetraazacyclododecane-1-ethyl acetate; DO3A-OEt; 1-(Ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1-Acetic Acid,Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity, meeting the exacting standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.