Description

6-Oxa-1-Azabicyclo[3.1.0]Hexane-2-Carboxylicacid,Ethylester,(2S,5S)-(9Ci) CAS NO 468096-98-2 is a high-purity, stereochemically defined bicyclic β-lactam derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its unique fused ring structure, which provides a versatile scaffold for the synthesis of novel, potent antibacterial agents and other bioactive molecules. This compound is essential for research and development laboratories and production facilities in the pharmaceutical and fine chemical industries focused on next-generation antibiotic discovery and development.

Application

• Key Intermediate in Antibiotic Synthesis: A vital building block for the production of novel carbapenem and penem class antibiotics.
• Medicinal Chemistry Research: Used as a core scaffold in structure-activity relationship (SAR) studies to develop new antimicrobial agents.
• Process Chemistry Development: Employed in route scouting and optimization for the commercial-scale manufacturing of complex active pharmaceutical ingredients (APIs).
• Fine Chemical Synthesis: Serves as a chiral synthon for constructing other complex, nitrogen- and oxygen-containing heterocycles with biological activity.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for client-specific drug development projects.
• Academic Research: Utilized in university and institutional labs for studying β-lactam chemistry, enzyme inhibition, and new synthetic methodologies.

Basic Information

Product Name	6-Oxa-1-Azabicyclo[3.1.0]Hexane-2-Carboxylicacid,Ethylester,(2S,5S)-(9Ci)
CAS No.	468096-98-2
Molecular Formula	C8H11NO3
Molecular Weight	169.18 g/mol
Synonyms	(2S,5S)-Ethyl 6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate; (2S,5S)-Ethyl 6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylic acid ester; (2S,5S)-6-Oxa-1-azabicyclo[3.1.0]hexane-2-carboxylic acid ethyl ester; Ethyl (2S,5S)-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate; (2S,5S)-6-Oxa-1-azabicyclo[3.1.0]hexane-2-carboxylic acid, ethyl ester; Bicyclic β-lactam ethyl ester; Fused oxazolidine-β-lactam intermediate; 468096-98-2
EINECS	Contact for details

Quality Control

Every batch of our 6-Oxa-1-Azabicyclo[3.1.0]Hexane-2-Carboxylicacid,Ethylester,(2S,5S)-(9Ci) is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (typically >97% by HPLC), chiral purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2S,5S)
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.