Description

4-Pyridineacetonitrile,α-Hydroxy-,(Alphar)-(9Ci) is a high-purity chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its unique pyridine-acetonitrile structure with an α-hydroxy group makes it a valuable precursor for constructing complex molecules with specific stereochemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators requiring specific stereoisomers.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the synthesis of specialty chemicals, dyes, and complex organic molecules for research and industrial applications.
• Academic and R&D Laboratories: A valuable compound for methodological studies in organic chemistry, particularly in stereoselective reactions.

Basic Information

Product Name	4-Pyridineacetonitrile,α-Hydroxy-,(Alphar)-(9Ci)
CAS No.	466686-68-0
Molecular Formula	C7H6N2O
Molecular Weight	134.14 g/mol
Synonyms	(R)-2-Hydroxy-2-(pyridin-4-yl)acetonitrile; (αR)-α-Hydroxy-4-pyridineacetonitrile; 4-Pyridineacetonitrile, α-hydroxy-, (αR)-; (R)-2-Hydroxy-2-(4-pyridyl)acetonitrile; (R)-2-(Pyridin-4-yl)-2-hydroxyacetonitrile; (R)-4-Pyridylglycolonitrile; (R)-α-Hydroxypicolinonitrile
EINECS	Contact for details

Quality Control

Our 4-Pyridineacetonitrile,α-Hydroxy-,(Alphar)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Consider storing under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.