Description

2-Pyridineacetonitrile,α-Hydroxy-,(Alphar)-(9Ci) is a high-purity chiral nitrile building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular architecture, which incorporates both a pyridine ring and a hydroxylated nitrile moiety, making it a versatile precursor for complex heterocyclic compounds. This product is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents. Its defined stereochemistry (Alphar) is critical for applications requiring precise molecular interactions.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially for central nervous system (CNS) and anti-infective therapies.
• Agrochemical Research: Used in the development of new herbicides and insecticides with specific modes of action.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated chiral ligands used in asymmetric catalysis.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex, high-value specialty chemicals and dyes.
• Academic & R&D: A valuable compound for methodological studies in organic chemistry and for exploring new synthetic pathways.

Basic Information

Product Name	2-Pyridineacetonitrile,α-Hydroxy-,(Alphar)-(9Ci)
CAS No.	466686-66-8
Molecular Formula	C8H8N2O
Molecular Weight	148.16 g/mol
Synonyms	(αR)-α-Hydroxy-2-pyridineacetonitrile; (R)-2-(2-Pyridyl)-2-hydroxyacetonitrile; (R)-2-Hydroxy-2-(pyridin-2-yl)acetonitrile; (R)-Pyridin-2-yl(hydroxy)acetonitrile; 2-Pyridineacetonitrile, α-hydroxy-, (αR)-; (R)-Cyanohydrin of 2-Pyridinecarboxaldehyde; (R)-2-Pyridylglycolonitrile
EINECS	Contact for details

Quality Control

Our 2-Pyridineacetonitrile,α-Hydroxy-,(Alphar)-(9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.