Description

4-(Methylthio)Phenylisocyanide is a specialized aromatic isocyanide derivative, a versatile and valuable building block in modern synthetic chemistry. Its unique structure, featuring both an isocyanide functional group and a methylthio substituent, makes it a critical reagent for constructing complex molecular frameworks, particularly in pharmaceutical and agrochemical research. This high-purity intermediate is essential for chemists and R&D teams in the fine chemical, pharmaceutical, and advanced material sectors seeking to develop novel compounds through multicomponent reactions and metal-catalyzed transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of heterocyclic compounds and active pharmaceutical ingredients (APIs) via Passerini and Ugi multicomponent reactions.
• Agrochemical Research: Used in the development of novel fungicides, herbicides, and insecticides, leveraging its role in creating diverse nitrogen-containing scaffolds.
• Material Science: Serves as a building block for functional polymers, ligands for catalysis, and metal-organic frameworks (MOFs).
• Chemical Synthesis: Employed in palladium-catalyzed isocyanide insertion reactions for the efficient construction of indoles, imidazoles, and other N-heterocycles.
• Ligand Synthesis: Useful for preparing specialized isocyanide-based ligands used in homogeneous catalysis and coordination chemistry.

Basic Information

Product Name	4-(Methylthio)Phenylisocyanide
CAS No.	463946-41-0
Molecular Formula	C8H7NS
Molecular Weight	149.21 g/mol
Synonyms	4-(Methylthio)phenyl isocyanide; p-(Methylthio)phenyl isocyanide; 1-Isocyano-4-(methylthio)benzene; 4-Methylsulfanylphenyl isocyanide; 4-(Methylmercapto)phenyl isocyanide; 4-Methylthiophenyl isonitrile; p-Methylthiophenyl isocyanide
EINECS	Contact for details

Quality Control

Our 4-(Methylthio)Phenylisocyanide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production applications. We employ advanced analytical techniques, including HPLC, GC, and NMR, to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the reactive nature of isocyanides, it is recommended to store under an inert atmosphere for long-term stability and to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Yellow to brown crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.