Description

4-Pyridinecarbonitrile, 3-(5-Bromo-2-Fluorophenyl)- is a high-value, multi-functional heterocyclic building block used in advanced organic synthesis. This compound is critical for research and development in the pharmaceutical and agrochemical sectors, where it serves as a key precursor for creating novel active molecules. Its unique structure, featuring bromo and fluoro substituents on a phenyl ring attached to a pyridinecarbonitrile core, makes it an essential intermediate for medicinal chemists and process development scientists. Global B2B clients rely on this high-purity intermediate for developing next-generation therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potential Active Pharmaceutical Ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of its halogenated aromatic system.
• Material Science Precursor: Serves as a starting material for synthesizing specialized ligands, catalysts, and functionalized polymers for advanced materials.
• Chemical Biology Probe Development: Employed in creating molecular probes and tags for studying biological pathways and protein interactions.
• Custom Synthesis & Scale-Up: A key substrate for contract research and manufacturing organizations (CROs/CMOs) offering custom synthesis services from milligram to kilogram scale.

Basic Information

Product Name	4-Pyridinecarbonitrile, 3-(5-Bromo-2-Fluorophenyl)-
CAS No.	462652-72-8
Molecular Formula	C12H6BrFN2
Molecular Weight	277.09 g/mol
Synonyms	3-(5-Bromo-2-fluorophenyl)isonicotinonitrile; 5-Bromo-2-fluoro-3-(4-cyanopyridin-3-yl)benzene; 3-(5-Bromo-2-fluorophenyl)-4-cyanopyridine; 4-Cyano-3-(5-bromo-2-fluorophenyl)pyridine; (5-Bromo-2-fluorophenyl)(4-cyanopyridin-3-yl); 3-(5-Bromo-2-fluorophenyl)pyridine-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-Pyridinecarbonitrile, 3-(5-Bromo-2-Fluorophenyl)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We provide material suitable for research and development, with the capability to scale production under cGMP guidelines for advanced clinical stage requirements. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.