Description

4-Cyclopentene-1,3-Diol, 1-[3-(Trimethylsilyl)-2-Propynyl]-, (1R,3S)- (9Ci) CAS NO 460990-23-2 is a high-purity, chiral organosilicon building block featuring a cyclopentene diol core and a trimethylsilyl-protected propargyl group. This compound is of significant value in advanced organic synthesis, particularly for its role as a key intermediate in the production of complex pharmaceutical molecules and novel materials. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in oncology and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced, enantiomerically pure pesticides and herbicides.
• Material Science Research: Serves as a precursor for silicon-containing polymers and advanced functional materials with tailored properties.
• Asymmetric Catalysis: Employed as a ligand precursor or a substrate in catalytic reactions to induce chirality.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems due to its modifiable alkyne handle.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and total synthesis projects.

Basic Information

Product Name	4-Cyclopentene-1,3-Diol, 1-[3-(Trimethylsilyl)-2-Propynyl]-, (1R,3S)- (9Ci)
CAS No.	460990-23-2
Molecular Formula	C11H18O2Si
Molecular Weight	210.35 g/mol
Synonyms	(1R,3S)-1-[3-(Trimethylsilyl)-2-propynyl]-4-cyclopentene-1,3-diol; (1R,3S)-1-(3-Trimethylsilyl-2-propynyl)-4-cyclopentene-1,3-diol; 1-(3-Trimethylsilylprop-2-yn-1-yl)-4-cyclopentene-1,3-diol, (1R,3S)-; (1R,3S)-1-(3-Trimethylsilylprop-2-ynyl)cyclopent-4-ene-1,3-diol; TMS-Propargyl Cyclopentenediol Derivative; Chiral TMS-Alkyne Diol; CAS 460990-23-2
EINECS	Contact for details

Quality Control

Our 4-Cyclopentene-1,3-Diol derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This compound is moisture-sensitive (hygroscopic) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.