Description

4'-Hydroxy-3'-Iodo-Biphenyl-4-Carbonitrile is a high-purity, halogenated biphenyl derivative of significant interest in advanced organic synthesis. This compound matters as a versatile and critical building block for constructing complex molecular architectures, particularly in pharmaceutical and materials science research. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as drug discovery and the development of advanced organic electronic materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its biphenyl core and functional handles for structural modification.
• Liquid Crystal & OLED Materials: Acts as a foundational unit for synthesizing advanced organic semiconductors and liquid crystal compounds for display technologies.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl systems.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorescent Probe Development: Employed in the design and synthesis of fluorescent markers and sensors for biochemical assays.

Basic Information

Product Name	4'-Hydroxy-3'-Iodo-Biphenyl-4-Carbonitrile
CAS No.	460746-47-8
Molecular Formula	C13H8INO
Molecular Weight	321.12 g/mol
Synonyms	3'-Iodo-4'-hydroxy-[1,1'-biphenyl]-4-carbonitrile; [1,1'-Biphenyl]-4-carbonitrile, 3'-iodo-4'-hydroxy-; 4-Cyano-3'-iodo-4'-hydroxybiphenyl; 4'-Hydroxy-3'-iodobiphenyl-4-carbonitrile; 3'-Iodo-4'-hydroxybiphenyl-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 4'-Hydroxy-3'-Iodo-Biphenyl-4-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and IR spectroscopy. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.