Description

8'-Chloro-5'-Hydroxy-1'H-Spiro[Cyclohexane-1,4'-Quinazolin]-2'(3'H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic quinazolinone structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel bioactive molecules and active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in drug discovery and development programs, particularly those targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates and novel chemical entities (NCEs).
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• API Synthesis: Employed in the development and scale-up production of potential Active Pharmaceutical Ingredients (APIs), especially those with spirocyclic architectures.
• Biochemical Research: Utilized as a tool compound or reference standard in biochemical assays and pharmacological studies.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for custom synthesis projects and process development.

Basic Information

Product Name	8'-Chloro-5'-Hydroxy-1'H-Spiro[Cyclohexane-1,4'-Quinazolin]-2'(3'H)-One
CAS No.	460346-10-5
Molecular Formula	C₁₄H₁₅ClN₂O₂
Molecular Weight	278.73 g/mol
Synonyms	8'-Chloro-5'-hydroxy-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one; 8'-Chloro-5'-hydroxy-1'H-spiro[cyclohexane-1,4'-quinazoline]-2'(3'H)-one; Spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one, 8'-chloro-5'-hydroxy-1'H-; 460346-10-5; 8-Chloro-5-hydroxy-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one; 8'-Chloro-5'-hydroxy-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one
EINECS	Contact for details

Quality Control

Our 8'-Chloro-5'-Hydroxy-1'H-Spiro[Cyclohexane-1,4'-Quinazolin]-2'(3'H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.