Description

8'-Chloro-5'-Methoxy-1'H-Spiro[Cyclohexane-1,4'-Quinazolin]-2'(3'H)-One is a high-purity, advanced pharmaceutical intermediate with the CAS number 460346-02-5. This compound is valued for its complex spirocyclic quinazolinone core, which serves as a critical building block in modern medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel bioactive molecules, particularly for applications in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Oncology Drug Development: Employed in the research and synthesis of potential kinase inhibitors and other anticancer agents.
• CNS-Active Compound Synthesis: Serves as a building block for developing compounds intended to cross the blood-brain barrier for neurological applications.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for chemical biology studies and novel heterocyclic chemistry exploration.

Basic Information

Product Name	8'-Chloro-5'-Methoxy-1'H-Spiro[Cyclohexane-1,4'-Quinazolin]-2'(3'H)-One
CAS No.	460346-02-5
Molecular Formula	C₁₅H₁₇ClN₂O₂
Molecular Weight	292.76 g/mol
Synonyms	8'-Chloro-5'-methoxyspiro[cyclohexane-1,4'(1'H)-quinazolin]-2'(3'H)-one; Spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one, 8'-chloro-5'-methoxy-1'H-; 460346-02-5; 8-Chloro-5-methoxy-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one; 8'-Chloro-5'-methoxy-1'H-spiro[cyclohexane-1,4'-quinazolin]-2'(3'H)-one
EINECS	Contact for details

Quality Control

Every batch of 8'-Chloro-5'-Methoxy-1'H-Spiro[Cyclohexane-1,4'-Quinazolin]-2'(3'H)-One is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound should be handled in a well-ventilated area and protected from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.