Description

1H-2,5-Epoxypyrido[1,2-C][1,3]Diazepine,3,4,5,5A,6,9-Hexahydro-,(5R,5Ar)- is a high-purity, stereochemically defined heterocyclic compound that serves as a critical advanced intermediate in modern pharmaceutical synthesis. Its complex fused-ring structure makes it a valuable building block for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in innovative drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery.
• Process Development & Scale-Up: Serves as a critical intermediate for optimizing synthetic routes from laboratory to pilot and commercial manufacturing scales.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial APIs under current Good Manufacturing Practice (cGMP) standards.
• Academic Research: Utilized in university and institutional labs for studying novel heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	1H-2,5-Epoxypyrido[1,2-C][1,3]Diazepine,3,4,5,5A,6,9-Hexahydro-,(5R,5Ar)-
CAS No.	460040-20-4
Molecular Formula	C9H12N2O
Molecular Weight	164.20 g/mol
Synonyms	(5R,5aR)-3,4,5,5a,6,9-Hexahydro-1H-2,5-epoxypyrido[1,2-c][1,3]diazepine; (5R,5aR)-Hexahydro-1H-2,5-epoxypyrido[1,2-c][1,3]diazepine; 460040-20-4; (5R,5aR)-1H-2,5-Epoxypyrido[1,2-c][1,3]diazepine, 3,4,5,5a,6,9-hexahydro-; Pyrido[1,2-c][1,3]diazepine epoxide derivative
EINECS	Contact for details

Quality Control

Our 1H-2,5-Epoxypyrido[1,2-C][1,3]Diazepine,3,4,5,5A,6,9-Hexahydro-,(5R,5Ar)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with full traceability are provided for every shipment. We can supply material compliant with current Good Manufacturing Practice (cGMP) guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (5R,5aR)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.